Local Stroke Research
The MAPS-2 Study: Metoclopramide and selective oral decontamination for
the prevention of pneumonia after stroke
Investigators A Warusevitane, J.
Sim, B. Helliwell, C. Smith, M Gosney, A Jeans, C. Roffe
Funding: NIHR HTA
The THROMBUS Study: Determinants of distal
embolization after mechanical thrombectomy
Investigators W. Jakobek, F.
Lally, S. Nayak, C. Roffe
The BOLUS study: Comparison of the metabolic
effects of intermittent versus continuous nasogastric feeding in patients
Investigators: F. Hanna, J.
Lancaster, J. Sim, C. Roffe
Funding: North Staffordshire
The MoTaStim Study
Chief Investigator: A. Aries
Funding: NIHR Doctoral
Recovery of walking is a
top-ten research priority for people after stroke. Although rehabilitation
does enhance walking recovery many people at six months after stroke are
unable to walk without assistance. Of those who regain independent walking
many remain unable to cross the road before the pedestrian lights change.
This project is focused on restoring sensation of the foot and ankle that is
crucial for balance and within-body (intrinsic) feedback during walking.
Therapy known as 'mobilisation and tactile stimulation' (MTS) provides somatosensory
stimulation which has been shown to improve recovery of the upper limb after
stroke. MTS is used clinically to improve recovery of the lower limb but
there is a paucity of research evidence for its use. An alternative means of
providing sensory stimulation is to wear textured insoles in the shoes but
again there is a paucity of research evidence. The aims of this project
are: (a) to develop a standardised protocol for MTS for the foot and ankle
iteratively with people with stroke and clinicians; (b) to develop a
standardised protocol for using in-shoe textured insoles iteratively with
people with stroke and clinicians; (c) to undertake a feasibility trial of
MTS and textured insoles in preparation for a subsequent clinical efficacy
trial. The results of this project will provide co-designed standardised
protocols for MTS and textured insoles for use in stroke rehabilitation and
inform the design of an adequately powered, randomised clinical trial to
compare MTS and textured insoles for their benefits on restoring walking
ability for people after stroke.