Local Stroke Research

The MAPS-2 Study: Metoclopramide and selective oral decontamination for the prevention of pneumonia after stroke
Investigators A Warusevitane, J. Sim, B. Helliwell, C. Smith, M Gosney, A Jeans, C. Roffe
Funding: NIHR HTA

The THROMBUS Study: Determinants of distal embolization after mechanical thrombectomy
Investigators W. Jakobek, F. Lally, S. Nayak, C. Roffe

The BOLUS study: Comparison of the metabolic effects of intermittent versus continuous nasogastric feeding in patients with stroke
Investigators: F. Hanna, J. Lancaster, J. Sim, C. Roffe
Funding: North Staffordshire Medical Institute

The MoTaStim Study
Chief Investigator: A. Aries
Funding: NIHR Doctoral Fellowship
 Recovery of walking is a top-ten research priority for people after stroke.  Although rehabilitation does enhance walking recovery many people at six months after stroke are unable to walk without assistance.  Of those who regain independent walking many remain unable to cross the road before the pedestrian lights change. This project is focused on restoring sensation of the foot and ankle that is crucial for balance and within-body (intrinsic) feedback during walking.  Therapy known as 'mobilisation and tactile stimulation' (MTS) provides somatosensory stimulation which has been shown to improve recovery of the upper limb after stroke. MTS is used clinically to improve recovery of the lower limb but there is a paucity of research evidence for its use. An alternative means of providing sensory stimulation is to wear textured insoles in the shoes but again there is a paucity of research evidence.  The aims of this project are: (a) to develop a standardised protocol for MTS for the foot and ankle iteratively with people with stroke and clinicians; (b) to develop a standardised protocol for using in-shoe textured insoles iteratively with people with stroke and clinicians; (c) to undertake a feasibility trial of MTS and textured insoles in preparation for a subsequent clinical efficacy trial.  The results of this project will provide co-designed standardised protocols for MTS and textured insoles for use in stroke rehabilitation and inform the design of an adequately powered, randomised clinical trial to compare MTS and textured insoles for their benefits on restoring walking ability for people after stroke.