MAPS-2 Study

The Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial: a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke

IRAS 290474 CPMS 50728 Twitter @MAPS2trial

The aim is to test whether giving metoclopramide 10 mg three times a day for 14 days prevents pneumonia and death after acute stroke.

Please click RANDOMIZE to randomize a participant and enter/edit data. It will take you to the RedCap site.

Please click STUDY DETAILS for a protocol summary, the EOI form, the study team, and our newsletters.

SAE reporting: See list of conditions which do not need to be reported as SAEs (Appendix 3) and list of SAE Diagnosis Categories sorted by Organ system to help identification of the correct term,

If you have had green light to open the study you will have to authorize your local team on the Redcap Website. You will need the invitation email you have been sent with the temoprary password.

Please watch this video to show how to give metoclopramide/saline administration via the nasogastric tube.

We have 1868 participants and 74 active centres plus 8 repatriation sites [21/07/2026]

  1. Stoke-on-Trent 24.02.22 (Dr Anushka Warusevitane Ass PI Dr Sushanth Shankar Dr Jude Okika) [239]
  2. London, Northwick Park Hospital 28.7.22 (Dr Aravinth Sivagnanaratnam, Ass Pi Dr Mirana Jahan) [96]
  3. Hull University Hospital 27.09.23 (Dr Bernard Esisi, Dr Rayessa Rayessa, Dr Dimitri Marantos ) [89]
  4. Cambridge, Addenbrooks University Hospital 27.7.22 (Dr Kayvan Khandjooi) [83]
  5. London, Royal London Hospital (Dr Oliver Spooner) [58]
  6. London, Imperial College Charing Cross Hospital 4.5.2023 (Dr Abid Malik) [57]
  7. Bury St Edmunds, West Suffolk Hospital 3.5.22 (Dr Abdul Azim to Aug 2026, Dr Tariq Soliman) [54]
  8. Crewe, Leighton H. 11.11.22 (Mrs Holly Maguire, Dr Hari Chandrashekar Ass PI Madeeha Yousuf 09/24) [49]
  9. Durham 19.5.22 (ANP Michelle Matthews) [39]
  10. Ulster, Northern Ireland SE HSCT 30.08.2023 (Dr Mark Bowman) [39]
  11. Leicester, University Hosptial 15.9.22 (Dr Kashif Musarrat) [39]
  12. Shrewsbury and Telford NHS Trust 1.11.2023 (Dr Indranil Mukhopadyay, Ass PI Sam Craik) [39]
  13. Bournemouth, Royal B. Hospital 12.10.22 (Dr Katharine Fairbairn Ass PI Anthony Smith, Filipa Santana) [36]
  14. Belfast, Royal Victoria Hospital 12.10.22 (Dr Patricia Fearon) [27]
  15. Southhampton Univ. H10.8.22 (Dr Shivaprasad Siddegowda, Ass PI Dr Ahmed Elserafy, Dr Ayesha Khan) [30]
  16. Wolverhampton New Cross Hospital 8.8.22 (Dr Nasar Ahmad) [36]
  17. Watford West Hertfordsire TH 27.2.22 (Dr Mohit Bhadari AssPI Dr Johan Arifin bin Roslan) [34]
  18. Middlesborough, James Cook Hosptial 27.6.22 (Mr Andrew Young) [32]
  19. Newcastle upon Tyne, Royal Victoria Infirmary 15.02.23 (Dr Michelle Davis) [30]
  20. Truro, Royal Cornwall Hosptial 21.8.22 (Dr Katja Adie) [26]
  21. London, King’s College 3.5.2023 (Dr Rohan Pathansali) [26]
  22. Sheffield Royal Hallamshire Hospital (DR Ali Ali) [26]
  23. Chelmsford, Broomfield Hospital 28.09.23 (Dr Ramanathan Kirtivasan Ass Pi Jaine Steffi John Melki) [26]
  24. London, UCLH 3.8.2023 (Dr Richard Perry) [26]
  25. Stockport, Stepping Hill Hosptial 15.11.23 (Dr Appukuttan Suman Ass PI Dr Bopage Kulathunga) [24]
  26. Leeds Teaching Hosptials 4.11.22 (Dr Vasileios Papavasileiou, AssPI Dr Rebecca Tremain) [24]
  27. Craigavon Southern Health and Social Care Trust NI 6.6.23 Recruting 1.5.24 (Dr Michael McCormick) [24]
  28. Nottingham, Queen’s Medical Centre 24.10.22 (Dr Senthil Raghnathan Ass Pi Dr Kamya Rangarajan) [23]
  29. London St George’s12.04.2023 (Dr Mihaylov [was Youssif Abousleiman till 04/2026], Ass PI Lizanne Dean) [23]
  30. Stockton-on-Tees, University Hosptial of North Tees 24.01.23 (Dr Sarah Whitehouse) [22]
  31. Epsom and St Helier 27.06.2023 (Dr Puneet Kakar) [21]
  32. York 5.6.2023 (Dr Luke Bridge) [19]
  33. Birmingham, University Hosptial of Birmingham 7.11.22 (Dr Mark Wilmot) [19]
  34. Exeter Royal Devon and Exeter 9.6.22 (Prof Martin James Ass PI Dr Alison Griffin) [19]
  35. Chester, Countess of Chester 12.07.22 (PI Prof Kausik Chatterjee, Ass PI Dr Pramodh Hettiarachchi) [19]
  36. Swansea, Morriston Hospital 11.5.22 (Dr Peter Slade) [19]
  37. Liverpool Aintree Liverpool University Hospitals NHSFT 1.09.2023 (Dr Thant Hlaing) [18]
  38. Fife, Kirkcaldy,Victoria Hosptial (11.09.2023) (Dr Vera Cvoro) [18]
  39. Carmarthen Glangwili GH 31.05.22 (Dr Pagdala Sridhar) [18]
  40. Luton and Dunstable University Hospital 7.12.22 (Dr Lakantha Alvis) [18]
  41. Doncaster 23.05.2023 (Dr Dinesh Cahdha) [18]
  42. Aberdeen 4.4.22 (Dr German Guzman Gutierrez Ass PI Dr Hazel Thompson) [18]
  43. Taunton, Musgrove Park Hospital 12.9.22 (Dr Babu Pusuluri) [17]
  44. Colchester Hospital (5.9.23) (Dr Ramachandran Sivakumar) [16]
  45. Dundee, Ninewells Hospital 28.11.22 (Dr Matt Lambert) [14]
  46. Northampton General Hospital NHS Trust 26.09.22 (Dr Venkatesan Srinivasan) [14]
  47. Sunderland, Royal Sunderland Hospital 29.4.22 (Dr Naweed Sattar) [13]
  48. Whiston St Helens and Knownsley 4.3.22 (Dr Sunanda Mavinamane) [12]
  49. Aberystwyth Bronglais Hospital 10.5.22 (Dr Syed Abid Raza) [12]
  50. Bradford Teaching Hospital NHS FT 27.06.2023 (Dr Numan Khan) [11]
  51. Carlisle North Cumbria Integrated Care NHSFT 6.3.23 (Dr Rachel Glover) [11]
  52. Derby, University Hospitals of Derby and Burton 13.01.23 (Dr Tim England, AssPI Dr Abdul Q. Aziz) [11]
  53. Halifax, Calderdale and Huddersfield NHS FT 27.01.23 2022 (Dr Syed Ahmad) [11]
  55. Hairmyres, Lanarkshire 5.5.23 (Dr Philip Birschel) [10]
  56. Antrim, Northern Healthcare Trust NI 23.05.2023 2.5.24 (Dr Murudappa Bhattad) [10]
  57. Withybush General Hospital 26.10.2024 (Dr Subramaniam Nagasay) [8]
  58. Wansbeck Cramlington Northumbria NHS FT 9.5.23 (Ms Anna Smith) [7]
  59. Manchester/Salford Northern Care Alliance FT 16.06.2023 (Prof Craig Smith) [6]
  60. Coventry (Usman Ghani)[6]
  61. Milton Keynes University Hospital NHS FT 1.9.22 (Dr Yousif Behnam) [5]
  62. Llanelli Prince Philip 30.3.22 (Dr Senthil Kumar) [5]
  63. Norwich, Norfolk and Norwich University Hospitals NHS FT 21.6.22 [5]
  64. Liverpool Arrowe Park Wirral University Hospitals NHS FT 18.11.22 (Dr Ruth Davies) [4]
  65. King’s Lynn, The Queen Elizabeth Hospital 8.4.2024 (Dr Raj Shekhar) [4]
  66. Gateshead Queen Elizabeth Hospital 8.3.23 (Ms Bev McClelland) [4]
  67. Dartford and Gravesham 11.12.24 (Dr Saeedur Rahman) [4]
  68. Dudley, Russel’s Hall [3]
  69. Glasgow Royal Infirmary 12.9.22 (Prof Terry Quinn) [3]
  70. Glasgow, Monklands 27.06.22 (Dr Mark Barber) [3]
  71. Basildon University Hospital 06.10.2023 (Dr Branimir Nevjada Ass Pi Dr Tabish Khan) [2]
  72. Edinburgh Royal Infrmary (26.02.2026) (Dr Fergus Doubal) [2]
  73. Enniskillen South West Acute Hosptital 07.09.2023 (Dr Breffni Keegan Ass PI Dr Brian Teehan) [1]
  75. Dorchester Dorset County H 23.03.23 (Dr Halald Proeschel)
  76. Betsi Cadwaladr University Health Board – Wrexham Maelor Hospital 6.1.25 DR Waleed Sayed)
  77. Rotherham District General Hospital 22.02.2024 (DR Ruhail Mir) REPATRIATION SITE
  78. Manchester Trafford GH (29.8.24 (Dr Tenence Kelly) REPATRIATION SITE

Associate PIS
Stoke: Sushanth Shankar 2022 Jude Okika Oct 2025
Bournemouth: Anthony Smith (withdrawn Sep 2023), Filipa Santana Oct 2023
Exeter: Alison Griffin Nov 2022
Chester: Pramodh Hettiarachchi 2022
Nottingham: Chaamanthi Menon; Jan 2023 Kamya Rangarajan
Aberdeen: Hazel Thompson 2022
Leeds: Rebecca Tremain May 2023
Enniskillen: Brian Teehan Nov 2023
Stockport: Bopage Kulathunga Nov 2023
Shrewsbury: Sam Craik Nov 2023; Sarah Millward May 2024
Manchester: Crystal SingChiek Teoh (tbc) Omar Al Shujari Feb 2024-apr 2024
Derby: Abdul Quayoume Aziz Mar 2024
Liverpool: Babajide Ogunlolu May 2024, Husna Bholah 2025
Sheffield: Daniel Johnson June 2024
Crewe: Madeeha Yousuf Sept 2024
Basildon: Hasan Abdulla July 2024, Tabish Khan 02/2025
Dundee: Joshua Gotom Oct 2024
Chelmsford : Janie Steffi John Melki (Nov 2024)
Northwick Park: Dr Mirana Jahan (Dec 2024)
Watford General Hospital: Johan Arifin bin Roslan (Feb 2025)
Southampton General Hospital: Dr Ayesha Khan (Feb 2025)
Liverpool Aintree: Dr Husana Bholah (Jul 2025)
Birmingham QE: Dr Muhammad Dawood Sohail (Sept 2025)
London, St George’s Lizanne Dean (Oct 2025)
Birmingham: Muhammad Dawood Sohail (completed Mar 2026)
Middlesborough James Cook: Nadine short (completed 05/2026)
London, Royal London Hospital: Lydia Obidi

Sites closed
Sandwell Hospital 1.11.22 (Dr Sissi Ispoglou) Closed 1 Mar 2023