MAPS-2 Study

The Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial: a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke

IRAS 290474 CPMS 50728 Twitter @MAPS2trial

The aim is to test whether giving metoclopramide 10 mg three times a day for 14 days prevents pneumonia and death after acute stroke.

Please click RANDOMIZE to randomize a participant and enter/edit data. It will take you to the RedCap site.

Please click STUDY DETAILS for a protocol summary, the EOI form, the study team, and our newsletters.

SAE reporting: See list of conditions which do not need to be reported as SAEs (Appendix 3) and list of SAE Diagnosis Categories sorted by Organ system to help identification of the correct term,

If you have had green light to open the study you will have to authorize your local team on the Redcap Website. You will need the invitation email you have been sent with the temoprary password.

Please watch this video to show how to give metoclopramide/saline administration via the nasogastric tube.

We have 1265 participants and 73 active centres plus 8 repatriation sites [5.3.25]

  1. Stoke-on-Trent 24.02.22 (Dr Anushka Warusevitane Ass PI Dr Sushanth Shankar) [161
  2. Cambridge, Addenbrooks University Hospital 27.7.22 (Dr Kayvan Khandjooi) [40]
  3. London, Northwick Park Hospital 28.7.22 (Dr Aravinth Sivagnanaratnam, Ass Pi Dr Mirana Jahan) [37]
  4. Crewe, Leighton Hospital 11.11.22 (Mrs Holly Maguire Ass PI Madeeha Yousuf 09/24) [34]
  5. Bury St Edmunds, West Suffolk Hopsital 3.5.22 (Dr Abdul Azim) [30]
  6. Durham 19.5.22 (ANP Michelle Matthews) [29]
  7. London, Royal London Hosptial (Dr Oliver Spooner) [28]
  8. Bournemouth, Royal B. Hosptial 12.10.22 (Dr Katharine Fairbairn Ass PI Anthony Smith, Filipa Santana) [26]
  9. Newcastle upon Tyne, Royal Victoria Infirmary 15.02.23 (Dr Michelle Davis) [24]
  10. Southhampton University Hospital 10.8.22 (Dr Shivaprasad Siddegowda, Ass PI Dr Ahmed Elserafy, Dr Ayesha Khan) [23]
  11. Truro, Royal Cornwall Hosptial 21.8.22 (Dr Katja Adie) [21]
  12. Exeter Royal Devon and Exeter 9.6.22 (Prof Martin James Ass PI Dr Alison Griffin) [20]
  13. Chester, Countess of Chester 12.07.22 (PI Prof Kausik Chatterjee, Ass PI Dr Pramodh Hettiarachchi) [19]
  14. Nottingham, Queen’s Medical Centre 24.10.22 (Dr Senthil Raghnathan Ass Pi Dr Chaamanthi Menon) [19]
  15. Leicester, University Hosptial 15.9.22 (Dr Kashif Musarrat) [19]
  16. Ulster, Northern Ireland SE HSCT 30.08.2023 (Dr Mark Bowman) [18]
  17. Stockton-on-Tees, University Hosptial of North Tees 24.01.23 (Dr Sarah Whitehouse) [18]
  18. Shrewsbury and Telford NHS Trust 1.11.2023 (Dr Indranil Mukhopadyay, Ass PI Sam Craik) [17]
  19. Wolverhampton New Cross Hosptial 8.8.22 (Dr Nasar Ahmad) [16]
  20. Leeds Teaching Hosptials 4.11.22 (Dr Vasileios Papavasileiou, AssPI Dr Rebecca Tremain) [15]
  21. Aberdeen 4.4.22 (Dr German Guzman Gutierrez Ass PI Dr Hazel Thompson) [15]
  22. Taunton, Musgrove Park Hospital 12.9.22 (Dr Babu Pusuluri) [15]
  23. York 5.6.2023 (Dr Luke Bridge) [13]
  24. London, Imperial College Charing Cross Hosptial 4.5.2023 (Dr Abid Malik) [12]
  25. Luton and Dunstable University Hosptial 7.12.22 (Dr Lakantha Alvis) [12]
  26. London, King’s College 3.5.2023 (Dr Rohan Pathansali) [12]
  27. Bradford Teaching Hospital NHS FT 27.06.2023 (Dr Numan Khan) [11]
  28. Birmingham, University Hosptial of Birmingham 7.11.22 (Dr Mark Wilmot) [11]
  29. Watford West Hertfordsire TH 27.2.22 (Dr Mohit Bhadari AssPI Dr Johan Arifin bin Roslan) [11]
  30. Belfast, Royal Victoria Hospital 12.10.22 (Dr Patricia Fearon) [11]
  31. Liverpool Aintree Liverpool Uinversity H hosptials NHSFT 1.09.2023 (Dr Thant Hlaing) [11]
  32. Aberystwyth Bronglais Hospital 10.5.22 (Dr Syed Abid Raza) [10]
  33. Middlesborough, James Cook Hosptial 27.6.22 (Mr Andrew Young) [10]
  34. Sunderland, Royal Sunderland Hospital 29.4.22 (Dr Naweed Sattar) [10]
  35. Swansea, Morriston Hosptial 11.5.22 (Dr Peter Slade) [10]
  36. Carlisle North Cumbria Integrated Care NHSFT 6.3.23 (Dr Rachel Glover) [9]
  37. Colchester Hosptital (5.9.23) (Dr Ramachandran Sivakumar) [9]
  38. Dundee, Ninewells Hosptial 28.11.22 (Dr Matt Lambert) [9]
  39. Hull University Hosptial 27.09.23 (Dr Bernard Esisi, Dr Rayessa Rayessa, Dr Dimitri Marantos ) [9]
  40. Northampton General Hospital NHS Trust 26.09.22 (Dr Venkatesan Srinivasan) [9]
  41. Whiston St Helens and Knownsley 4.3.22 (Dr Sunanda Mavinamane) [8]
  42. London, UCLH 3.8.2023 (Dr Richard Perry) [8]
  43. Craigavon Southern Health and Social Care Trust NI 6.6.23 Recruting 1.5.24 (Dr Michael McCormick) [8]
  44. North cumbria Integrated Care [8]
  45. Carmarthen Glangwili GH 31.05.22 (Dr Pagdala Sridhar) [8]
  46. Hairmyres, Lanarkshire 5.5.23 (Dr Philip Birschel) [7]
  47. Epsom and St Helier 27.06.2023 (Dr Puneet Kakar) [7]
  48. London St George’s12.04.2023 (Dr Youssif Abousleiman) [7]
  49. Stockport, Stepping Hill Hosptial 15.11.23 (Dr Appukuttan Suman Ass PI Dr Bopage Kulathunga) [7]
  50. Fife, Victoria Hosptial (11.09.2023) (Dr Vera Cvoro) [8]
  51. Doncaster 23.05.2023 (Dr Dinesh Cahdha) [5]
  52. Huddersfield, Calderdale and Huddersfield NHS FT 27.01.23 2022 (Dr Syed Ahmad) [4]
  53. Milton Keynes University Hopstial NHS FT 1.9.22 (Dr Yousif Behnam) [4]
  54. Chelmsford, Broomfield Hospital 28.09.23 (Dr Ramanathan Kirtivasan Ass Pi Jaine Steffi John Melki) [4]
  55. King’s Lynn, The Queen Elizabeth Hosptial 8.4.2024 (Dr Raj Shekhar) [4]
  56. Sheffield Royal Hallamshire Hospital (DR Ali Ali) [4]
  57. Derby, University Hosptials of Derby and Burton 13.01.23 (Dr Tim England, AssPI Dr Abdul Q. Aziz) [4]
  58. Norwich, Norfolk and Norwich University Hospitals NHS FT 21.6.22 [3]
  59. Antrim, Northern Healthcare Trust NI 23.05.2023 2.5.24 (Dr Murudappa Bhattad) [3]
  60. Glasgow Royal Infirmary 12.9.22 (Prof Terry Quinn) [3]
  61. Glasgow, Monklands 27.06.22 (Dr Mark Barber) [3]
  62. Wansbeck Northumbria NHS FT 9.5.23 (Ms Anna Smith) [3]
  63. Basildon University Hosptial 06.10.2023 (Dr Branimir Nevjada Ass Pi Dr Tabish Khan)
  64. Manchester/Salford Northern Care Alliance FT 16.06.2023 (Prof Craig Smith) [2]
  65. Llanelli Prince Philip 30.3.22 (Dr Senthil Kumar) [2]
  66. Liverpool Arrowe Park Wirral University Hospitals NHS FT 18.11.22 (Dr Ruth Davies) [2]
  67. Coventry [1]
  68. Dorchester Dorset County H 23.03.23 (Dr Halald Proeschel)
  69. Gateshead Queen Elizabeth Hosptial 8.3.23 (Ms Bev McClelland)
  70. Enniskillen South West Acute Hosptital 07.09.2023 (Dr Breffni Keegan Ass PI Dr Brian Teehan)
  71. Rotherham District General Hospital 22.02.2024 (DR Ruhail Mir) REPATRIATION SITE
  72. Manchester Trafford GH (29.8.24 (Dr Tenence Kelly) REPATRIATION SITE
  73. Withybush General Hospital 26.10.2024 (Dr Subramaniam Nagasay)
  74. Dartford and Gravesham 11.12.24 (Dr Saeedur Rahman)
  75. Betsi Cadwaladr University Health Board – Wrexham Maelor Hospital 6.1.25 DR Waleed Sayed)

Accociate PIS
Basildon: Tabish Khan 02/2025
Stoke: Sushanth Shankar 2022
Bournemouth: Anthony Smith (withdrawn Sep 2023), Filipa Santana Oct 2023
Exeter: Alison Griffin Nov 2022
Chester: Pramodh Hettiarachchi 2022
Nottingham: Chaamanthi Menon Jan 2023
Aberdeen: Hazel Thompson 2022
Leeds: Rebecca Tremain May 2023
Enniskillen: Brian Teehan Nov 2023
Stockport: Bopage Kulathunga Nov 2023
Shrewsbury: Sam Craik Nov 2023; Sarah Millward May 2024
Manchester: Crystal SingChiek Teoh (tbc) Omar Al Shujari Feb 2024-apr 2024
Derby: Abdul Quayoume Aziz Mar 2024
Liverpool: Babajide Ogunlolu May 2024
Sheffield: Daniel Johnson June 2024
Crewe: Madeeha Yousuf Sept 2024
Basildon: Hasan Abdulla July 2024
Dundee: Joshua Gotom Oct 2024
Chelmsford : Janie Steffi John Melki (Nov 2024)
Northwick Park: Dr Mirana Jahan (Dec 2024)
Watford General Hospital: Johan Arifin bin Roslan (Feb 2025)
Southampton General Hosptial: Dr Ayesha Khan (Feb 2025)

Sites closed
Sandwell Hospital 1.11.22 (Dr Sissi Ispoglou) Closed 1 Mar 2023