MAPS-2 Study

The Metoclopramide for Avoiding Pneumonia after Stroke (MAPS-2) Trial: a single-blind, randomized controlled trial of metoclopramide for the prevention of pneumonia in patients with dysphagia after an acute stroke

IRAS 290474 CPMS 50728 Twitter @MAPS2trial

The aim is to test whether giving metoclopramide 10 mg three times a day for 14 days prevents pneumonia and death after acute stroke.

Please click RANDOMIZE to randomize a participant and enter/edit data. It will take you to the RedCap site.

Please click STUDY DETAILS for a protocol summary, the EOI form, the study team, and our newsletters.

SAE reporting: See list of conditions which do not need to be reported as SAEs (Appendix 3) and list of SAE Diagnosis Categories sorted by Organ system to help identification of the correct term,

If you have had green light to open the study you will have to authorize your local team on the Redcap Website. You will need the invitation email you have been sent with the temoprary password.

Please watch this video to show how to give metoclopramide/saline administration via the nasogastric tube.

We have 770 participants and 68 active centres plus 2 repatriation sites [01.05.24]

  1. Stoke-on-Trent 24.02.22 (Dr Anushka Warusevitane Ass PI Dr Sushanth Shankar) [141]
  2. Cambridge, Addenbrooks University Hospital 27.7.22 (Dr Kayvan Khandjooi) [33]
  3. Durham 19.5.22 (ANP Michelle Matthews) [28]
  4. London, Northwick Park Hospital 28.7.22 (Dr Aravinth Sivagnanaratnam) [28]
  5. Bury St Edmunds, West Suffolk Hopsital 3.5.22 (Dr Abdul Azim) [26]
  6. Bournemouth, Royal B. Hosptial 12.10.22 (Dr Katharine Fairbairn Ass PI Anthony Smith, Filipa Santana) [26]
  7. London, Royal London Hosptial (Dr Oliver Spooner) [25]
  8. Crewe, Leighton Hospital 11.11.22 (Mrs Holly Maguire) [25]
  9. Southhampton University Hospital 10.8.22 (Dr Shivaprasad Siddegowda, Ass |PI Dr Ahmed Elserafy) [23]
  10. Newcastle upon Tyne, Royal Victoria Infirmary 15.02.23 (Dr Michelle Davis) [21]
  11. Truro, Royal Cornwall Hosptial 21.8.22 (Dr Katja Adie) [20]
  12. Chester, Countess of Chester 12.07.22 (PI Prof Kausik Chatterjee, Ass PI Dr Pramodh Hettiarachchi) [19]
  13. Exeter Royal Devon and Exeter 9.6.22 (Prof Martin James Ass PI Dr Alison Griffin) [18]
  14. Nottingham, Queen’s Medical Centre 24.10.22 (Dr Senthil Raghnathan Ass Pi Dr Chaamanthi Menon) [18]
  15. Stockton-on-Tees, University Hosptial of North Tees 24.01.23 (Dr Sarah Whitehouse) [18]
  16. Leicester, University Hosptial 15.9.22 (Dr Kashif Musarrat) [15]
  17. Leeds Teaching Hosptials 4.11.22 (Dr Vasileios Papavasileiou, AssPI Dr Rebecca Tremain) [15]
  18. Aberdeen 4.4.22 (Dr German Guzman Gutierrez Ass PI Dr Hazel Thompson) [14]
  19. Taunton, Musgrove Park Hospital 12.9.22 (Dr Babu Pusuluri) [14]
  20. Ulster, Northern Ireland SE HSCT 30.08.2023 (Dr Mark Bowman) [14]
  21. London, Imperial College Charing Cross Hosptial 4.5.2023 (Dr Abid Malik) [12]
  22. York 5.6.2023 (Dr Luke Bridge) [11]
  23. Luton and Dunstable University Hosptial 7.12.22 (Dr Lakantha Alvis) [11]
  24. Shrewsbury and Telford NHS Trust 1.11.2023 (Dr Indranil Mukhopadyay, Ass PI Sam Craik) [11]
  25. Aberystwyth Bronglais Hospital 10.5.22 (Dr Syed Abid Raza) [10]
  26. Wolverhampton New Cross Hosptial 8.8.22 (Dr Nasar Ahmad) [10]
  27. Birmingham, University Hosptial of Birmingham 7.11.22 (Dr Mark Wilmot) [10]
  28. Middlesborough, James Cook Hosptial 27.6.22 (Mr Andrew Young) [9]
  29. Northampton General Hospital NHS Trust 26.09.22 (Dr Venkatesan Srinivasan) [9]
  30. Sunderland, Royal Sunderland Hospital 29.4.22 (Dr Naweed Sattar) [9]
  31. Watford West Hertfordsire TH 27.2.22 (Dr Mohit Bhadari) [9]
  32. London, King’s College 3.5.2023 (Dr Rohan Pathansali) [9]
  33. Carlisle North Cumbria Integrated Care NHSFT 6.3.23 (Dr Rachel Glover) [9]
  34. Belfast, Royal Victoria Hospital 12.10.22 (Dr Patricia Fearon) [9]
  35. Liverpool Aintree Liverpool Uinversity H hosptials NHSFT 1.09.2023 (Dr Thant Hlaing) [8]
  36. Bradford Teaching Hospital NHS FT 27.06.2023 (Dr Numan Khan) [8]
  37. Whiston St Helens and Knownsley 4.3.22 (Dr Sunanda Mavinamane) [8]
  38. Colchester Hosptital (5.9.23) (Dr Ramachandran Sivakumar) [7]
  39. Epsom and St Helier 27.06.2023 (Dr Puneet Kakar) [7]
  40. Dundee, Ninewells Hosptial 28.11.22 (Dr Matt Lambert) [7]
  41. Hairmyres, Lanarkshire 5.5.23 (Dr Philip Birschel) [5]
  42. London St George’s12.04.2023 (Dr Youssif Abousleiman) [6]
  43. Carmarthen Glangwili GH 31.05.22 (Dr Pagdala Sridhar) [5]
  44. Swansea, Morriston Hosptial 11.5.22 (Dr Peter Slade) [5]
  45. Hull University Hosptial 27.09.23 (Dr Bernard Esisi, Dr Rayessa Rayessa, Dr Dimitri Marantos ) [4]
  46. Huddersfield, Calderdale and Huddersfield NHS FT 27.01.23 2022 (Dr Syed Ahmad) [4]
  47. Stockport, Stepping Hill Hosptial 15.11.23 (Dr Appukuttan Suman Ass PI Dr Bopage Kulathunga) [4]
  48. Milton Keynes University Hopstial NHS FT 1.9.22 (Dr Yousif Behnam) [4]
  49. Doncaster 23.05.2023 (Dr Dinesh Cahdha) [4]
  50. London, UCLH 3.8.2023 (Dr Richard Perry) [4]
  51. Glasgow Royal Infirmary 12.9.22 (Prof Terry Quinn) [3]
  52. Glasgow, Monklands 27.06.22 (Dr Mark Barber) [3]
  53. Sheffield Royal Hallamshire Hospital (DR Ali Ali) [3]
  54. Fife, Victoria Hosptial (11.09.2023) (Dr Vera Cvoro) [3]
  55. Chelmsford, Broomfield Hospital 28.09.23 (Dr Ramanathan Kirtivasan) [3]
  56. Derby, University Hosptials of Derby and Burton 13.01.23 (Dr Tim England, AssPI Dr Abdul Q. Aziz) [2]
  57. Llanelli Prince Philip 30.3.22 (Dr Senthil Kumar) [2]
  58. Wansbeck Northumbria NHS FT 9.5.23 (Ms Anna Smith) [1]
  59. Liverpool Arrowe Park Wirral University Hospitals NHS FT 18.11.22 (Dr Ruth Davies) [1]
  60. Antrim, Northern Healthcare Trust NI 23.05.2023 (Dr Murudappa Bhattad) [1]
  61. King’s Lynn, The Queen Elizabeth Hosptial 8.4.2024 (Dr Raj Shekhar) [1]
  62. Norwich, Norfolk and Norwich University Hospitals NHS FT 21.6.22 (Dr Joyce Balami)
  63. Dorchester Dorset County H 23.03.23 (Dr Halald Proeschel)
  64. Gateshead Queen Elizabeth Hosptial 8.3.23 (Ms Bev McClelland)
  65. Craigavon Southern Health and Social Care Trust NI 6.6.23 Recruting 1.5.24 (Dr Michael McCormick)
  66. Manchester/Salford Northern Care Alliance FT 16.06.2023 (Prof Craig Smith)
  67. Enniskillen South West Acute Hosptital 07.09.2023 (Dr Breffni Keegan Ass PI Dr Brian Teehan)
  68. Basildon University Hosptial 06.10.2023 (Dr Branimir Nevjada)
  69. Rotherham District General Hospital 22.02.2024 (DR Ruhail Mir) REPATRIATION SITE
  70. Northern Trust, NI 2.5.2024 (Dr Murudappa Bhattad)

Accociate PIS

Stoke: Sushanth Shankar 2022
Bournemouth: Anthony Smith (withdrawn Sep 2023), Filipa Santana Oct 2023
Exeter: Alison Griffin Nov 2022
Chester: Pramodh Hettiarachchi 2022
Nottingham: Chaamanthi Menon Jan 2023
Aberdeen: Hazel Thompson 2022
Leeds: Rebecca Tremain May 2023
Enniskillen: Brian Teehan Nov 2023
Stockport: Bopage Kulathunga Nov 2023
Shrewsbury: Sam Craik Nov 2023; Sarah Millward May 2024
Manchester: Crystal SingChiek Teoh (tbc) Omar Al Shujari Feb 2024-apr 2024
Derby: Abdul Quayoume Aziz Mar 2024
Liverpool: Babajide Ogunlolu May 2024
Sheffield: Daniel Johnson June 2024

Sites closed

Sandwell Hospital 1.11.22 (Dr Sissi Ispoglou) Closed 1 Mar 2023